We had no idea that our recently acquired dream home would completely upend our life until we discovered a hidden area. We had to move out as a result of what we discovered inside, but we had no idea that this nightmare would bring about an unforeseen turn of events.
I never imagined that I would wake up in a horror movie, yet that is exactly where I am. For years, Jack and I had been saving money to purchase our first house. I was ecstatic when we eventually received the keys. We immediately got to work on the improvements, with me leading the way while Jack concentrated on his task.
“Liv, you sure you’re okay managing all this?” The night before the renovations started, Jack inquired. Encircled by boxes, we reclined on our air mattress that we had borrowed.
I rolled my eyes. “I can handle this. Mr. Big Shot, you put your work first.”
Jack laughed and drew me in. “All right, all right. Just don’t enjoy yourself excessively without me.”
Everything was normal on Tuesday morning, until it changed. As I was enjoying my coffee and browsing through my phone, Carlos, the leader of our renovation team, contacted me.
He exclaimed, “Olivia, you gotta see this.”
Curious about what they’d discovered, I strolled over. Carlos gestured to a piece of the wall they had recently demolished. There was a door there, concealed by years of paint and drywall.
I said, “What do you think it is?”
Carlos gave a shrug. “I have no idea. Would you like to open it?”
I reached for the doorknob and nodded. I opened the creaking door and looked inside. My enthusiasm soon gave way to fear. Shuddering, I slammed the door shut.
“What’s wrong?” Carlos enquired, his expression filled with worry.
I was unable to talk. Reaching for my phone, I punched in Jack’s number. He detected the third ring.
“Hi Liv. What’s going on?”
“Jack, you must return home. Right now.”
“What? Why? Is everything in order?
Taking a deep breath, I tried to control my voice. Something was discovered inside the home. You must view it.
Jack didn’t dispute, so he must have heard the panic in my voice. “I’m on my way.”
I paced back and forth in front of the secret entrance while I waited for Jack. Although Carlos and his team continued to work, I could sense their wondering looks.
“You okay, Olivia?” Carlos paused his efforts to ask.
I nodded, not believing I could talk. My mind was buzzing with ideas. And what if it was a haunted house? What if we had discovered a sinister secret?
Jack was panting heavily when he got there. “Olivia, what’s going on?”
Taking his hand, I guided him towards the entrance. I remarked, “Look,” and carefully opened it.
Jack gasped in shock at what he saw. There were ancient garments in the concealed area that had originally been a closet. The worst part, though, wasn’t that. Insects crawled all over, and mold covered the garments. There was an overpowering smell, and spiders had taken up residence in the corners.
Jack mumbled, “Holy —,” and slammed the door. “How long has that been there?”
I gave a headshake. “I’m not sure. It was never brought up by the realtor.”
For a few while, we stood there in quiet, taking in what we had just witnessed. At last, Jack said something.
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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