I thought my big business trip to LA was going to be just another day until a mysterious request from the pilot left me questioning everything I knew about my past. The truth he shared would alter my future in ways I never imagined.
My flight to Los Angeles was supposed to be a smooth one, but what happened during that two-hour journey changed my life forever. But before I tell you about it, let me share why I had to reach LA that day.
So, I work as an architect at a well-known construction firm, and this is my dream job. Let me tell you, it wasn’t good luck that brought me here. It was my hard work and all those sleepless nights I spent in college upgrading my skills and learning new concepts.
Recently, my boss gave me an opportunity to present a big project to some of our top investors in Los Angeles.
It was a HUGE thing because it could lead to a long-awaited promotion, so I happily accepted the opportunity.
Honestly, I felt so grateful for it because it was also a chance to make my mom, Melissa, proud. She’s my best friend, and that’s mainly because she has raised me as a single parent. She told me my father passed away before I was born, but she never stopped me from chasing my dreams. Mom’s always been there to support me, and I love her for that.
So, when I told her about the meeting in LA, she hugged me and said, “Go get ’em, sweetie! I’ll be praying for you.”
The time flew by at the airport, and soon I found myself comfortably seated on the plane, ready to take off. The flight attendants were all so welcoming, and I lucked out with an empty seat next to me!
As the plane began to ascend, I couldn’t help but feel excited. I was well-prepared for my presentation, hoping the investors would like it.
A few minutes into the flight, a friendly-looking flight attendant named Bethany approached me with a tray of drinks.
“Can I get you something to sip on?” she asked with a smile.
“Just orange juice, please,” I replied, raising my hand to accept the glass. As I did, Bethany glanced down at the birthmark on my wrist.
“I’m sorry, could I have your passport, please?” she asked suddenly.
Well, that’s strange, I thought.
Confused but not wanting to argue, I handed it over. Bethany looked it over carefully before returning it with a nod.
“Just a standard protocol check. Thank you!”
Sounds cool.
A short while later, Bethany returned to my seat.
“Excuse me, will you be in a rush after we land?” she asked.
“Yeah, I’ve got a connecting flight to catch and I’m already running late,” I explained as I subconsciously clasped my hands together.
“Well, the pilot wants to speak with you after we land.”
“The pilot?” I asked. “Why? Can’t he just talk to me now?”
“I’m afraid not,” Bethany replied in a serious tone. “He wants to talk to you in person. I know you’re in a hurry, but trust me, you’ll want to hear this. You’ll regret it if you don’t.”
I sat there, utterly perplexed.
What on earth could the pilot possibly need to tell me? And why did it have to wait until after we landed? My big meeting was hanging in the balance, and I didn’t want to risk missing my connection. But Bethany’s insistence made me feel like this was something important.
As the plane touched down and the other passengers began filing out, I steeled myself and waited patiently for the pilot to approach.
When the cabin was finally empty, a tall man with graying hair entered, his eyes immediately locking onto mine.
At that point, I literally dropped my bag and jacket. My jaw just about hit the floor because I could’ve sworn I had seen this man before.
I instantly recognized him from old photos my mom had shown me. This was Steve, her childhood friend.
But the man didn’t look happy to see me.
In fact, tears were streaming down his face as he threw his arms around me in a tight embrace. I stood there, completely bewildered, as he sobbed into my shoulder.
“What’s going on?” I asked in a shaky voice. “What happened?”
He pulled away, gazing at me with red-rimmed eyes. Then, he gently took my hand and revealed a birthmark on his wrist. It was an exact match to the one on mine.
“Courtney,” he choked out, “I’m your father.”
“Wait, what?” I looked at him with eyes wide open. “My father? But Mom said…”
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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